A similar study by Xu and team revealed that the hucMSC-exosome relieves macrophage pyroptosis to ameliorate murine colitis by inhibiting caspase 11 activation and reducing the release of IL-1β, IL-6, and caspase 11.HucMSC exosomes repaired the distorted structure of the colon epithelium (276). This evidence concerns the gene IL1B and colitis.