The exact cause of ALS has not been fully elucidated, however the accumulation of aggregates of misfolded proteins such as mutant superoxide dismutase 1, fused in sarcoma, ubiquilin 2, TAR DNA-binding protein 43, and peptides derived from intronic repeats of the C9ORF72 gene are key pathological hallmarks (132–134). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.