FBXW7 and cancer: FBXW7 can inhibit the transcriptional activation of the CCL2 gene by negatively regulating the expression level of NOTCH; inhibition of CCL2/CCR2 signal transduction has been shown to inhibit tumor metastasis, indicating that the FBXW7/NOTCH/CCL2 axis plays an important role in regulating cancer metastasis (28).