VEGFA and neoplasm: In addition, the interaction between β-TrCP and Akt is particularly significant under hypoxic conditions: hypoxia induces Akt hydroxylation and inhibits its activity, while β-TrCP may affect the survival and angiogenesis of tumor cells by regulating Akt stability, further promoting the secretion of immunosuppressive angiogenesis factors (such as VEGF) (15).