In addition, the interaction between β-TrCP and Akt is particularly significant under hypoxic conditions: hypoxia induces Akt hydroxylation and inhibits its activity, while β-TrCP may affect the survival and angiogenesis of tumor cells by regulating Akt stability, further promoting the secretion of immunosuppressive angiogenesis factors (such as VEGF) (15). The gene discussed is BTRC; the disease is neoplasm.