The heatmap presents the top five upregulated (PLVAP, DIPK2B, CD34, TOMM40L, SLC26A6) and downregulated (CLEC4M, CLEC1B, STAB2, BMP10, BMPER) genes in HCC samples (Supplementary Figure S8B). The gene discussed is TOMM40L; the disease is hepatocellular carcinoma.