CD244 and acute lymphoblastic leukemia: Our study extends this relevance to radiation-induced T-ALL, showing that CD8+ T cells activated by LMP1/2A+B cells exhibit increased NKG2D expression, which enhances their ability to recognize and eliminate tumors lacking MHC class I. In future studies, we plan to use MHC class I-deficient tumor models or MHC class I–neutralizing antibodies to completely block the classical killing pathway, in order to further evaluate the roles of NKG2D, 2B4, and other potential mechanisms.