Although the percentage of hematopoietic stem and progenitor cells, a source of T-ALLs, was not disturbed, GCB-LMP1/2A mice had significantly higher percentages of CD8+ memory T cells in the bone marrow and thymus compared with control mice, suggesting that CD8+ T cell-mediated immune surveillance plays an important role in the suppression of T-ALL. This evidence concerns the gene PDLIM7 and acute lymphoblastic leukemia.