Although originally defined in pancreatic cancer, myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs) exhibit conserved gene expression programs in ccRCC as well—myCAFs express TGF-β response genes and ECM components, while iCAFs secrete IL-6, LIF, and CXCL8, which amplify immunosuppression and tumor-promoting inflammation (7, 8). This evidence concerns the gene TGFB1 and neoplasm.