Tolerogenic Lactobacillus probiotics reduced Th1/Th17 cell populations, elevated Tregs and IL-10, suppressed pro-inflammatory cytokines (IL-17, IFN-γ) and autoantibodies (ANA, anti-dsDNA, anti-RNP), diminished lipogranuloma mass, and delayed SLE progression in pristane-induced lupus mice (120). Here, RNPC3 is linked to systemic lupus erythematosus.