A. muciniphila and L. plantarum alleviated SLE in mice by reducing systemic inflammation, lowering IL-6 and IL-17 levels, elevating IL-10, restoring gut barrier integrity, diminishing renal IgG deposition, and enhancing kidney function, likely through immune modulation and gut microbiota regulation (77). The gene discussed is IL6; the disease is systemic lupus erythematosus.