IFNG and systemic lupus erythematosus: This augmented height can lead to the production of pro-inflammatory cytokines such as IFN-γ, which promotes B cell class switching and initiates pathogenic autoantibodies production such as Immunoglobulin G (IgG) antibodies, most notably anti-dsDNA antibodies, typical lupus-characteristic markers, that induce additional inflammation and tissue damage (115, 118).