The study demonstrates their impact to reduced anti-dsDNA, ANA, and anti-RNP antibodies, alleviated proteinuria and disease severity, boosted CD4+ CD25+ FoxP3+ Tregs, lowered IL-6, and elevated IL-10 and TGF-β, collectively ameliorating SLE symptoms in pristane-induced lupus mice (134). This evidence concerns the gene CD4 and systemic lupus erythematosus.