LRP6 and tooth agenesis: We summarized 48 LRP6 variants linked to congenital tooth agenesis in humans, and identified a novel truncating variant (c.2182C>T, p. Arg728*) and two novel missense variants [c.3773C>T (p.Thr1258Met) and c.1441C>T (p.Arg481Cys)].