Patients with LRP6-associated congenital tooth agenesis most frequently lacked upper lateral incisors and upper and lower second premolars, while upper central incisors and first and second molars were relatively unaffected, aligning with findings reported by Chu et al., 2021; Chu et al., 2021; Zhang et al., 2021; Zhang et al., 2021). Here, LRP6 is linked to tooth agenesis.