Polymorphisms in CLOCK (Hoffman et al., 2010; Truong et al., 2014), NPAS2 (Zhu et al., 2008), CRY2 (Hoffman et al., 2010), RORA (Truong et al., 2014), TIMELESS (Fu et al., 2012), and ARNTL (Zienolddiny et al., 2013) have been associated with breast cancer. The gene discussed is CRY2; the disease is breast cancer.