For example, NOS3 rs2070744C>T and rs1799983T>G have been shown to affect susceptibility to essential hypertension (Gamil et al., 2017; Jemaa et al., 2007; Amrani-Midoun et al., 2019; Nassereddine et al., 2018) and response to enalapril (Masilela et al., 2021) whereas NOS3 rs3918188C>A has been reported to be associated with enalapril response among Brazilians, with NOS3 rs3918188A allele carriers showing lower decreases in BP (Oliveira-Paula et al., 2016a). This evidence concerns the gene NOS3 and essential hypertension.