In this study, five SMRGs [including Arylsulfatase B (ARSB), N-Acylsphingosine Amidohydrolase 1 (ASAH1), Galactosidase Beta 1 (GLB1), Hexosaminidase Subunit Beta (HEXB), and Prosaposin (PSAP)] were selected as biomarkers for PD. This evidence concerns the gene GLB1 and Parkinson disease.