PSAP and early-onset autosomal dominant Alzheimer disease: PSAP was predominantly enriched in the lysosome, chemokine signaling pathway, spliceosome, oxidative phosphorylation, alzheimer’s disease, regulation of actin cytoskeleton, FC gamma R-mediated phagocytosis, oxidative phosphorylation, Leishmania infection, hematopoietic cell lineage, and other pathways (Figures 3D–H).