It has also been shown that PSAP was highly expressed in macrophages and may participate in Ribosomal protein S6 kinase beta-1 (S6K1) signaling by regulating the phosphorylation of the RPS6-encoded ribosomal protein S6, which regulated the metabolic reprogramming of macrophages and their mediated inflammatory responses, thereby affecting the progress of PD. This evidence concerns the gene PSAP and Parkinson disease.