RPS6KB1 and Parkinson disease: It has also been shown that PSAP was highly expressed in macrophages and may participate in Ribosomal protein S6 kinase beta-1 (S6K1) signaling by regulating the phosphorylation of the RPS6-encoded ribosomal protein S6, which regulated the metabolic reprogramming of macrophages and their mediated inflammatory responses, thereby affecting the progress of PD.