Markers including Carbohydrate Antigen (CA) 50, CA19-9, CA125, CA724, CA242, ferritin, leukocyte count, high-sensitivity C-reactive protein (HS-CRP), total bilirubin, direct bilirubin, alanine aminotransferase, and aspartate aminotransferase were significantly higher in the severe acute pancreatitis (SAP) and moderately severe acute pancreatitis (MSAP) groups compared to the mild acute pancreatitis (MAP) group (P < 0.05). The gene discussed is GPT; the disease is acute pancreatitis.