Importantly, no mutations were detected in other known EV-associated or immunodeficiency-related genes, such as RHOH, IL7, CORO1A, STK4, DOCK8, or CARMIL2, supporting the notion that the identified TMC6 and TMC8 variants may represent the primary genetic contributors in this case (11–13). The gene discussed is TMC6; the disease is Immunodeficiency.