(ii) Antineutrophil Cytoplasmic Antibody (ANCA) Positivity, in particular cytoplasmic ANCA (c-ANCA) or anti-proteinase 3 (PR3-ANCA), is included in the criteria with a weight of −3 points, reflecting the fact that ANCA positivity is less common in EGPA compared to other ANCA-associated vasculitides like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) (38). The gene discussed is PRTN3; the disease is granulomatosis with polyangiitis.