Other IEIs associated with hypereosinophilia or eosinophilia are phosphoglucomutase 3 (PGM3) deficiency, adenosine deaminase Immunodeficiency, Omenn syndrome, Loeys-Dietz Syndrome, Wiskott-Aldrich syndrome, autoimmune lymphoproliferative syndrome, Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome, Comel-Netherton syndrome, and Severe Dermatitis, Multiple Allergies, and Metabolic Wasting (SAM) Syndrome (45). The gene discussed is PGM3; the disease is skin disorder.