While Aβ plaques develop at early stages of AD (Nordberg, 2004), cognitive impairment and neurodegeneration are observed as tau NFTs begin to develop (Brier et al., 2016;Nelson et al., 2012) with a strong spatial correlation (Gordon et al., 2018;La Joie et al., 2020). The gene discussed is MAPT; the disease is Cognitive impairment.