SFRP2 and systemic sclerosis: Some of the fibroblast phenotypes reported above have also been observed in additional studies of atopic dermatitis (AD), such as COL1A1+ fibroblasts [21], or in the related conditions localized scleroderma (LS) and systemic sclerosis (SSc) where SFRP2+ and CCL19+ fibroblasts have been previously found [22, 23].