They demonstrate pathological TDP-43 inclusions and are associated with heterogeneous phenotypic presentations.47 Indeed, evidence shows that C9orf72+ and GRN+ exhibit high rates of NPS such as psychosis during their symptomatic stages.48, , , –52 Longitudinally, NPS may progress in a genetic group-specific manner as exemplified by a predominance of depression and anxiety throughout the disease stages in GRN+ . The gene discussed is C9orf72; the disease is major depressive disorder.