The potential of aptamers has beendemonstrated for the detectionof ricin, mycotoxins, as well as for interleukin-6 (IL-6) and PCT, in low volume samplesfrom neonates using aptamer-modified graphene micromotors, which alloweven for dual assays. A cutting-edgemicromotor dual OFF–ON aptassay has been reported for the simultaneousdetermination of both early sepsis biomarkers, PCT and IL-6, in 15min using only 2 μL of the sample from low-birthweight neonateswith a gestational age of less than 32 weeks and birth weight below1000 g, with clinical suspicion of late-onset sepsis. This evidence concerns the gene IL6 and Onset.