But in glioma, when cells are stimulated by driving factors such as K‐Ras, B‐Raf mutations, PGK1 can activate pyruvate dehydrogenase kinase 1 (PDHK1) phosphorylation, suppressing the tricarboxylic acid (TCA) cycle ultimately promoting tumour growth. This evidence concerns the gene PGK1 and central nervous system cancer.