The main findings can be summarized as follows: (i) NT‐proBNP levels were independently and quantitatively associated with the composite endpoint of all‐cause mortality or HF hospitalization within 3 years; (ii) while the mMIDA score initially showed an association with the primary endpoint, this association lost significance after adjusting for NT‐proBNP; and (iii) real‐world PMR patients undergoing M‐TEER represent a heterogeneous population, as reflected by the wide range of NT‐proBNP levels, with continuous risk increase across the whole range of NT‐proBNP levels (Graphical Abstract). This evidence concerns the gene NPPB and hydrops fetalis.