PALM and neoplasm: In terms of cytoskeletal dynamics and adhesion, PALM may inhibit cell migration and invasion through pathways such as the Rho GTPase signaling or integrin-mediated adhesion; in apoptosis regulation, it might promote apoptosis via the mitochondrial apoptosis pathway or death receptor pathway; in angiogenesis and lymphangiogenesis, it could suppress relevant signaling pathways to limit tumor metastasis and growth; additionally, it may induce cell cycle arrest by regulating cyclin-related factors.