As depicted in Fig. S1A, the administered plasmids included: (1) Kras + HPV + SONIC system[SONIC-KrasG12D-Luc-E7-E6 donor, H513 pX330.sgActin.UTR.2, and sgA]; and (2) Nras + HPV + SB system[Pkt2-Luc-T2a-E7-T2a-E6, pT/Caggs-NRasV12, and pCMV(CAT)T7-SB100]. As tumor growth was previously shown to correlate with bioluminescence signal [34, 42], mice were imaged weekly in the IVIS Spectrum following i.p. injection of luciferin to measure signal from buccal tumors (Fig. 2A). Here, KRAS is linked to neoplasm.