ETFDH and multiple acyl-CoA dehydrogenase deficiency: The three most common missense variations in ETFDH are c.250G > A (A84T, 237/894), c.770A > G (Y257C, 86/894), and c.1130T > C (L337P, 68/894) in late-onset MADD patients with biallelic variations, and c.250G > A (A84T, 6/42), c.1227A > C (L409F, 5/42), and c.770A > G (Y257C, 4/42) in those with single heterozygous variations (Fig. 2).