Our findings underscore the promising role of icariin in the management of animal DN, where it demonstrated beneficial effects on renal function markers (SCR、BUN, 24 h UP, 24 h UV, and KI), inflammatory biomarkers (IL-1β), oxidative stress parameters (SOD,GPX, MDA), and risk factors (TG, TC). Here, SOD1 is linked to liver dysplastic nodule.