Comparison of the expression levels of six model genes (G6PD, LCAT, SERPINE1, SOAT2, CYP2C9, UGT1A10) in 369 HCC tissues and 50 adjacent HCC tissues from the TCGA-LIHC cohort showed that G6PD, UGT1A10 and SOAT2 were highly expressed in HCC tissues and lowly expressed in the adjacent tissues, while LCAT, SERPINE1 and CYP2C9 were lowly expressed in HCC tissues and highly expressed in the adjacent tissues. This evidence concerns the gene G6PD and hepatocellular carcinoma.