Of note, GWAS has some limitations, as: a) miRNAs are rarely prioritized in GWAS due to their regulatory roles, but transcriptomic studies link miR-342-5p to insulin signaling (e.g., suppression of IRS1 in adipose tissue) and miR-636 to autophagy in diabetic nephropathy. The gene discussed is IRS1; the disease is diabetic kidney disease.