Within the subgroup of patients with HFpEF and T2DM, IL1RL1 levels were positively associated with increasing LA minimal volume (r = 0.57, p = 0.041) and with both end-diastolic (r = 0.69, p = 0.009) and end-systolic (r = 0.75, p = 0.003) volumes. This evidence concerns the gene IL1RL1 and type 2 diabetes mellitus.