The results showed that high-leveled DCDC2 significantly activated the PI3K-AKT signaling in ICC cells (Fig. 3A), and the top-scored biological process included Hallmark PI3K-Akt-MTOR signaling (Fig. 3B), KEGG CXCR-GNB/PI3K-Akt signaling pathway and KEGG KSHV vGPCR to GNB/G-PI3K-Akt signaling pathway. The gene discussed is MTOR; the disease is intrahepatic cholangiocarcinoma.