The same is true for the histone methyltransferase PRDM9 which leads to meiotic defects and thus infertility in mice (Brick et al, 2012; Hayashi et al, 2005), while in humans an individual identified with LOF variants in the PRDM9 gene was healthy and fertile (Narasimhan et al, 2016a). This evidence concerns the gene PRDM9 and Infertility.