While SEMA3F suppresses U87 migration via the NRP2/PLXNA1 receptor complex [40], SEMA3A suppresses brain tumor stem cell proliferation but enhances migration through NRP1/PLXNA1 complex, and PLXNA1-knockdown reduced the growth of GBM in an mice model [41]. The gene discussed is PLXNA1; the disease is glioblastoma.