By excluding all the shared mutation and circumscribing the analysis to the partially shared/unique mutations, i.e. the mutations allegedly acquired after the neoplastic transformation [11, 13], again a significant skewing of hotspot mutations was documented in IDhigh M-CLL cases, indicative of an ongoing activity of the AID/Polη-dependent machinery (Figure S14). Here, POLH is linked to B-cell chronic lymphocytic leukemia.