Based on the analysis of immunophenotypic profiles in 189 CLL (112 IDlow, 77 IDhigh M-CLL), we showed no significant difference in term of MFI expression between IDlow and IDhigh M-CLL, the majority of cases in both groups expressing a typical CLL immunophenotype (i.e. CD5+/CD23+/CD43+ with variable/dim expression of CD20/FMC7, as well as variable/dim expression of CD79b/SmIg/IgM; Figure S13) [27, 28]. The gene discussed is CD5; the disease is B-cell chronic lymphocytic leukemia.