BCR and B-cell chronic lymphocytic leukemia: Moreover, one can speculate that the ID process may contribute to increase a BCR-related generation of neoantigen expressed on CLL cells [38, 64], as suggested by a higher rate of replacement mutations in the FR3 region of IDhigh M-CLL similarly seen in other LPD [64], with a subsequent more effective control of the CLL clone by reactive immune cells.