On average, participants with diabetes were older than those with prediabetes and those with normoglycemia (56.3 ± 11.2 yrs vs 50.8 ± 12.1 and 47.2 ± 11.9 yrs, respectively, p < 0.001), had higher CD4:CD8 ratio (p = 0.04), had higher BMI (34.4 ± 7.4 kg/m2 vs 32.5 ± 6.8 and 30.5 ± 6.6 kg/m2, respectively, p < 0.001), and had a slightly longer duration of HIV (18.2 ± 9.9 vs 16.2 ± 9.3 and 14.5 ± 9.2 yrs, respectively, p = 0.09). This evidence concerns the gene CD4 and prediabetes syndrome.