As shown in Fig. 5F and Fig S5G, forced expression of GAB1 or Myr-GAB1 significantly promoted the tumor growth, with average tumor volumes reaching 300 mm3, 825 mm3, or 1655 mm3 at the end of experiment for SUNE-1-V, SUNE-1-GAB1 or SUNE-1-Myr-GAB1 xenografts respectively. The gene discussed is GAB1; the disease is neoplasm.