Short-term high-fat diets are proposed to perturb skeletal muscle DNA methylation, with observed hypomethylation at loci linked to T1D (Type 1 diabetes), while aberrant methylation signatures may drive autoimmune activation in T1D pathogenesis, this is partly because HFD induces DNA demethylation of genes involved in energy storage, a process that is effectively inhibited by MBD2 knockdown [73]. Here, MBD2 is linked to type 1 diabetes mellitus.