In NSCLC, GPX2 promotes epithelial-mesenchymal transition (EMT) and metastasis by activating the PI3K/AKT/mTOR/Snail signaling axis through the clearance of ROS [21], but the function of GPX2 on EGFR-TKI resistance remains unclear. The gene discussed is GPX2; the disease is non-small cell lung carcinoma.