The observed cytokine profile suggests a robust activation of NK cells, characterized by enhanced cytolytic activity (granzyme B), pro‐inflammatory responses (IFN‐γ and TNFα),21, 22 and potential recruitment and modulation of other immune cells within the tumor milieu (GROα known as a CXCL1)23 (Figure 4d). This evidence concerns the gene GZMB and neoplasm.