For instance, in a transgenic mouse model, overexpression of human SHBG protected against high-fat diet induced obesity and insulin resistance, mediated through induction of lipolysis in white adipose tissue, suggesting that this liver-derived factor can directly influence adipose tissue through a previously unexplored liver-to-adipose tissue signaling axis [16]. Here, SHBG is linked to obesity due to melanocortin 4 receptor deficiency.