Contrary, the lipolytic phenotype associated with low SHBG, manifested as low catecholamine-induced lipolysis despite high levels of basal lipolysis, reflects metabolic inflexibility and is a key determinant of impairments in adipocyte metabolic health and has been shown to predict weight gain and insulin resistance over time [22,39,45,46]. The gene discussed is SHBG; the disease is Insulin resistance.