At the same time, GWAS show that specific polymorphisms in the SHBG gene, associated with low concentrations of circulating SHBG, predict an increased risk of lipid metabolic diseases and type 2 diabetes, partly through increased ectopic lipid deposition, indicating that SHBG per se exerts systemic metabolic effects [[11], [12], [13], [14]]. This evidence concerns the gene SHBG and type 2 diabetes mellitus.