In both CD14+ monocytes and B cells we found significant time × severity interactions for “allograft rejection” pathways and in CD14 monocytes for “graft-versus-host disease,” “asthma,” “type 1 diabetes,” and “systemic lupus erythematosus.” Examination of the genes that make up these pathways revealed that these signals were largely driven by distinct temporal patterns of HLA expression. This evidence concerns the gene CD14 and systemic lupus erythematosus.