TNF and neoplasm: Coupling cytokines with specific targeting moieties, such as fibronectin-binding IL-15 and IL-2,14,15 tumor vessel-targeting tumor necrosis factor (TNF) alpha and LIGHT,16,17 anti-CD20-RLI,18 and collagen-binding IL-12,19,20 enables precise delivery of cytokines to specific cell types within the TME.