In the tumor microenvironment, IL‐10 and IL‐35 were differentially expressed by Treg subpopulations[55, 56, 57, 58 and collaboratively promoted T cell exhaustion.[59] Notably, we found that IL‐35, rather than IL‐10, is the predominant immunosuppressive cytokine in GHCer‐induced Treg cells. This evidence concerns the gene IL10 and neoplasm.