The effects of lifestyle changes and hormonal contraceptives on circulating incretinlevels have been explored in women with PCOS through secondary analysis of arandomized controlled trial (12).The group receiving oral hormonal contraception exhibited a significant suppressionof plasma OXM levels, a response not induced by lifestyle interventions.Furthermore, the impact of metformin on the incretin axis was evaluated in PCOSpatients over an eight-month period, showing an increase in GIP and GLP-1 levelspost-intervention (13). This evidence concerns the gene GIP and polycystic ovary syndrome.