Sondorp et al. developed a patient-derived thyroid cancer organoid model, and although similarities in TSHR expression were observed between papillary thyroid cancer (PTC) tissue and organoids, the expression levels of PAX8, TG, c-MET, and TSHR decreased in thyroid cancer organoids during passaging, suggesting the dedifferentiation of these organoids during propagation (83). This evidence concerns the gene TSHR and thyroid cancer.