Approximately 41% of the NF-κB-associated genes analyzed in the primary mixed glia cultures were downregulated (fold regulation of -2 or less) in RML-scrapie-infected IKK KO microglia-limited cultures compared to RML-infected WT mixed glia (S2 Fig and S1 Table for complete list). This evidence concerns the gene NFKB1 and scrapie.