Although semaglutide treatment alone induced anorexia (Fig. 4I) and body weight loss (Fig. 4J), GIP-085 cotreatment partially reduced hypophagia, and consequently, this resulted in a marginal yet significant attenuation of the body weight lowering effect of semaglutide treatment at 24 and 48 hours. The gene discussed is GIP; the disease is Anorexia.