In the SEA region, the mutation spectrum of BRCA1 and BRCA2 genes in breast cancer has been studied in Singaporean [18,19,29–31], Malaysian [21,32–37], Filipino [38,39], Vietnamese [40,41], Thai [42,43], and Indonesian [44,45] populations leading to the discovery of novel pathogenic variants from different ethnicities, suggesting that mutation spectrum of the BRCA1 and BRCA2 genes are still understudied in the region. The gene discussed is BRCA1; the disease is breast carcinoma.