An unbiased analysis using The Cancer Genome Atlas (TCGA) datasets (31) revealed that UBR4 mRNA expression was significantly higher in LUAD tumor samples (N = 510) than that in normal lung tissue samples (N = 59; P = 0.0014 from unpaired and P = 0.0085 from paired Student t tests; Fig. 1A). Here, UBR4 is linked to neoplasm.