Dysregulation of RhoGDI in internal adenomyosis, which regulates Rho GTPases involved in cell migration, adhesion, and proliferation and is related to multiple human cancers [43], could enhance the invasive properties of endometrial cells, contributing to their ability to penetrate and grow within the myometrium; interestingly, enhanced RhoGDI and PTEN have been recently described in adenomyosis and have been linked to pregnancy disorders in these patients [26]. This evidence concerns the gene ARHGDIA and cancer.