PON1 and coronary artery disorder: HDL-C, as an independent protective factor in CHD, can directly antagonize the effects of ox-LDL on endothelial cells and smooth muscle cells, and its antioxidant capacity is mainly derived from proteins related to HDL-C, such as PON1 (paraoxonase-1, human paraoxonase-1) and ApoA-1 (apolipoprotein A-1).