In their analysis of 27 individuals with obesity compared to 27 age- and sex-matched controls, Nigro et al. (38) found a slightly higher expression of adiponectin in obese patients compared to controls (obese patients: 6.1±1.3 ng/mL, controls: 4.8±2.6 ng/mL). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.