Therefore, the aim of the present study was to evaluate the influence of genetic polymorphisms in ACE (Ins/Del), FAM13A (rs2609255), FAS (rs2234767), FASLG (rs763110), IL1RN (rs419598 and rs2234663), NOS2 (rs2297518), TGFB1 (rs1800469), and TNF (rs1800629) on TB susceptibility in 143 Brazilian patients with silicosis. The gene discussed is NOS2; the disease is tuberculosis.