TNF and tuberculosis: Therefore, the aim of the present study was to evaluate the influence of genetic polymorphisms in ACE (Ins/Del), FAM13A (rs2609255), FAS (rs2234767), FASLG (rs763110), IL1RN (rs419598 and rs2234663), NOS2 (rs2297518), TGFB1 (rs1800469), and TNF (rs1800629) on TB susceptibility in 143 Brazilian patients with silicosis.